Brain damage in the epileptic beagle dog.

نویسندگان

  • D L Montgomery
  • A C Lee
چکیده

Brain lesions associated with seizures in an epilepsy-prone colony of beagle dogs were studied in 68 dogs which died as a result of the disorder. Approximately 48.5% of the dogs had a relatively specific pattern of acute brain damage on microscopic examination. In all affected areas, there was a triad of lesions consisting of perineuronal and perivascular astrocytic swelling, perineuronal basophilic incrustations, and ischemic cell change in neurons. The most common areas of involvement were the cerebral cortex, basal nuclei, claustrum, amygdala, septal nuclei, dorsal thalamic nuclei, isthmus of the pyriform lobe, and hippocampus. The cerebellum was affected only rarely. In addition, intraneuronal inclusions identical to Lafora's bodies found in myoclonus epilepsy of man were detected in thalamic nuclei of six dogs.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Grey matter volume in healthy and epileptic beagles using voxel-based morphometry – a pilot study

BACKGROUND One of the most common chronic neurological disorders in dogs is idiopathic epilepsy (IE) diagnosed as epilepsy without structural changes in the brain. In the current study the hypothesis should be proven that subtle grey matter changes occur in epileptic dogs. Therefore, magnetic resonance (MR) images of one dog breed (Beagles) were used to obtain an approximately uniform brain sha...

متن کامل

The effect of silymarin on prevention of hippocampus neuronal damage in rats with temporal lob epilepsy

Background and Objective: Temporal lobe epilepsy is hallmarked with neuronal degeneration in some areas of hippocampus and mossy fiber sprouting in dentate area. Considering some evidences on neuroprotective and antioxidant activity of silymarin (SM), this study was undertaken to evaluate the preventive effect of this agent on structural changes in hippocampus of kainate-epileptic rats. Materia...

متن کامل

Effect of Ocimum basilicum hydro-alcoholic extract on oxidative damage of brain tissue following seizures induced by pentylenetetrazole in mice

Introduction: A relationship between epileptic seizures and brain tissue oxidative damage has been suggested. Ocimum basilicum (O. basilicum) has been shown to have beneficial effects including hypnotic and protective against tissue oxidative damage. The present study was designed to evaluate the effects of O. basilicum hydro-alcoholic extract on oxidative damage of brain tissue following s...

متن کامل

Control of epileptic seizures by electrical low frequency deep brain stimulation: A review of probable mechanisms

Epilepsy is the most common neurological disease with no definitive method in treatment. Notably, the main way to treat and control epileptic seizures is drug therapy. However, about 20-30% of patients with epilepsy are drug resistant and require other therapeutic manners. Deep brain stimulation is a new therapeutic strategy for these patients. Conspicuously, there are no clear answers for basi...

متن کامل

A simple and rapid high-performance liquid chromatographic method with UV detection is developed and validated to determine the concentration of voriconazole in rat and beagle dog plasma. After protein precipitation using acetonitrile, the supernatant solution is chromatographed on a Diamonsil

method with UV detection is developed and validated to determine the concentration of voriconazole in rat and beagle dog plasma. After protein precipitation using acetonitrile, the supernatant solution is chromatographed on a Diamonsil C18 column (250 × 4.6-mm i.d., 5 μm). The mobile phase used is a combination of acetonitrile–water–acetic acid (55:45:0.25, v/v/v) with a pH of 4.0. Detection is...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Veterinary pathology

دوره 20 2  شماره 

صفحات  -

تاریخ انتشار 1983